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Article

New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors.

Scientific reports - 23 Mar 2016

Kowalski Thayne Woycinck, Fraga Lucas Rosa, Tovo-Rodrigues Luciana, Sanseverino Maria Teresa Vieira, Hutz Mara Helena, Schuler-Faccini Lavínia, Vianna Fernanda Sales Luiz

Abstract excerpt

Antiangiogenic properties of thalidomide have created an interest in the use of the drug in treatment of cancer. However, thalidomide is responsible for thalidomide embryopathy (TE). A lack of knowledge regarding the mechanisms of thalidomide teratogenesis acts as a barrier in the aim to synthesize a safer analogue of thalidomide. Recently, our group detected a higher frequency of alleles that impair the...

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Identifiers

PMID: 27004986
DOI: 10.1038/srep23404
PMCID: PMC4804217

Genes

NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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