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Article

Polymorphisms in the endothelial nitric oxide synthase gene in thalidomide embryopathy.

Nitric oxide : biology and chemistry - 30 Nov 2013

Vianna Fernanda Sales Luiz, Fraga Lucas Rosa, Tovo-Rodrigues Luciana, Tagliani-Ribeiro Alice, Biondi Flavia, Maximino Claudia Marques, Sanseverino Maria Teresa Vieira, Hutz Mara Helena, Schuler-Faccini Lavínia

Abstract excerpt

Thalidomide is one of the most potent teratogens known to humans. It is currently used for many clinical situations such as treatment of leprosy reactions and multiple myeloma. However, the teratogenic mechanisms by which it produces morphological defects still remain unclear. One of the hypotheses is the blockage of angiogenesis by reduction of nitric oxide (NO). In this study, we evaluated two functional...

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Identifiers

PMID: 24055736
DOI: 10.1016/j.niox.2013.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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