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Article

Genetic susceptibility to thalidomide embryopathy in humans: Study of candidate development genes.

Birth defects research - 15 Mar 2018

Gomes Julia do Amaral, Kowalski Thayne Woycinck, Fraga Lucas Rosa, Tovo-Rodrigues Luciana, Sanseverino Maria Teresa Vieira, Schuler-Faccini Lavínia, Vianna Fernanda Sales Luiz

Abstract excerpt

Thalidomide is a drug used worldwide for several indications, but the molecular mechanisms of its teratogenic property are not fully understood. Studies in animal models suggest the oxidative stress, the inhibition of angiogenesis, and the binding to E3-ubiquitin ligase complex as mechanisms by which thalidomide can change the expression of genes important to embryonic development. In this study, seven...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29193903
DOI: 10.1002/bdr2.1163

Genes

BMP4
FGF10
FGF8
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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