Article
Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jun 2017
Kowalski Thayne Woycinck, Fraga Lucas Rosa, Tovo-Rodrigues Luciana, Sanseverino Maria Teresa Vieira, Hutz Mara Helena, Schuler-Faccini Lavínia, Vianna Fernanda Sales Luiz
Abstract excerpt
Thalidomide embryopathy (TE) has affected more than 10,000 babies worldwide. The hypothesis of antiangiogenesis as the teratogenic mechanism of thalidomide has been investigated in several experimental models; but, in humans, it has only been accessed by in vitro studies. Here, we hypothesized the effect of thalidomide upon angiogenesis-related molecules or proteins, previously identified in human embryonic...
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