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The BIN1 rs744373 Alzheimer's disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2022

Franzmeier Nicolai, Ossenkoppele Rik, Brendel Matthias, Rubinski Anna, Smith Ruben, Kumar Atul, Mattsson-Carlgren Niklas, Strandberg Olof, Duering Marco, Buerger Katharina, Dichgans Martin, Hansson Oskar, Ewers Michael

Abstract excerpt

INTRODUCTION: The BIN1 rs744373 single nucleotide polymorphism (SNP) is a key genetic risk locus for Alzheimer's disease (AD) associated with tau pathology. Because tau typically accumulates in response to amyloid beta (Aβ), we tested whether BIN1 rs744373 accelerates Aβ-related tau accumulation. METHODS: We included two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI], n = 153; Biomarkers for...

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PMID: 34060233
DOI: 10.1002/alz.12371

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