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Article

MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1.

The Journal of cell biology - 28 Mar 2016

Zhao Wei, Liu Jie, Zhang Xiaoming, Deng Lih-Wen

Abstract excerpt

Faithful chromosome segregation with bipolar spindle formation is critical for the maintenance of genomic stability. Perturbation of this process often leads to severe mitotic failure, contributing to tumorigenesis. MLL5 has been demonstrated to play vital roles in cell cycle progression and the maintenance of genomic stability. Here, we identify a novel interaction between MLL5 and PLK1 in the cytosol that is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27002166
DOI: 10.1083/jcb.201501021
PMCID: PMC4810297

Genes

PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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