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Article

Polo-like Kinase 1 as an emerging drug target: structure, function and therapeutic implications

4 Sept 2020

Abstract excerpt

Polo-like kinase 1 (PLK1) is a conserved mitotic serine-threonine protein kinase, functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It plays important roles in the regulation of cell division, maintenance of genome stability, in spindle assembly, mitosis, and DNA-damage response. PLK1 is consist of a N-terminal serine-threonine kinase domain, and a C-terminal Polo-box...

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PMID: 32886539
DOI: 10.1080/1061186x.2020.1818760

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