Article
Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation.
Biochemical and biophysical research communications - 13 Oct 2006
Feng Yang, Yuan Jin Hui, Maloid Sharon C, Fisher Rebecca, Copeland Terry D, Longo Dan L, Conrads Thomas P, Veenstra Timothy D, Ferris Andrea, Hughes Steve, Dimitrov Dimiter S, Ferris Douglass K
Abstract excerpt
Polo-like kinase functions are essential for the establishment of a normal bipolar mitotic spindle, although precisely how Plk1 regulates the spindle is uncertain. In this study, we report that the small GTP/GDP-binding protein Ran is associated with Plk1. Plk1 is capable of phosphorylating co-immunoprecipitated Ran in vitro on serine-135 and Ran is phosphorylated in vivo at the same site during mitosis when Plk1...
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