Article
Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies.
Antimicrobial agents and chemotherapy - 1 Jun 2016
Mita Toshihiro, Culleton Richard, Takahashi Nobuyuki, Nakamura Masatoshi, Tsukahara Takahiro, Hunja Carol W, Win Zin Zayar, Htike Wah Win, Marma Aung S, Dysoley Lek, Ndounga Mathieu, Dzodzomenyo Mawuli, Akhwale Willis S, Kobayashi Jun, Uemura Haruki, Kaneko Akira, Hombhanje Francis, Ferreira Marcelo U, Björkman Anders, Endo Hiroyoshi, Ohashi Jun
Abstract excerpt
The emergence and spread of artemisinin-resistant Plasmodium falciparum is of huge concern for the global effort toward malaria control and elimination. Artemisinin resistance, defined as a delayed time to parasite clearance following administration of artemisinin, is associated with mutations in the Pfkelch13 gene of resistant parasites. To date, as many as 60 nonsynonymous mutations have been identified in this...
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