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Article

Leveraging protein quaternary structure to identify oncogenic driver mutations.

BMC bioinformatics - 22 Mar 2016

Ryslik Gregory A, Cheng Yuwei, Modis Yorgo, Zhao Hongyu

Abstract excerpt

BACKGROUND: Identifying key "driver" mutations which are responsible for tumorigenesis is critical in the development of new oncology drugs. Due to multiple pharmacological successes in treating cancers that are caused by such driver mutations, a large body of methods have been developed to differentiate these mutations from the benign "passenger" mutations which occur in the tumor but do not further progress the...

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Identifiers

PMID: 27001666
DOI: 10.1186/s12859-016-0963-3
PMCID: PMC4802602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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