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Article

A spatial simulation approach to account for protein structure when identifying non-random somatic mutations.

BMC bioinformatics - 3 Jul 2014

Ryslik Gregory A, Cheng Yuwei, Cheung Kei-Hoi, Bjornson Robert D, Zelterman Daniel, Modis Yorgo, Zhao Hongyu

Abstract excerpt

BACKGROUND: Current research suggests that a small set of "driver" mutations are responsible for tumorigenesis while a larger body of "passenger" mutations occur in the tumor but do not progress the disease. Due to recent pharmacological successes in treating cancers caused by driver mutations, a variety of methodologies that attempt to identify such mutations have been developed. Based on the hypothesis that...

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Identifiers

PMID: 24990767
DOI: 10.1186/1471-2105-15-231
PMCID: PMC4227039

Genes

ALK
BRAF
CHRM2
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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