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Article

A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.

BMC bioinformatics - 26 Mar 2014

Ryslik Gregory A, Cheng Yuwei, Cheung Kei-Hoi, Modis Yorgo, Zhao Hongyu

Abstract excerpt

BACKGROUND: It is well known that the development of cancer is caused by the accumulation of somatic mutations within the genome. For oncogenes specifically, current research suggests that there is a small set of "driver" mutations that are primarily responsible for tumorigenesis. Further, due to recent pharmacological successes in treating these driver mutations and their resulting tumors, a variety of...

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Source

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Identifiers

PMID: 24669769
DOI: 10.1186/1471-2105-15-86
PMCID: PMC4024121

Genes

DPP4
EGFR
KRAS
NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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