Article
Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes.
Scientific reports - 26 May 2016
Fujimoto Akihiro, Okada Yukinori, Boroevich Keith A, Tsunoda Tatsuhiko, Taniguchi Hiroaki, Nakagawa Hidewaki
Abstract excerpt
Protein tertiary structure determines molecular function, interaction, and stability of the protein, therefore distribution of mutation in the tertiary structure can facilitate the identification of new driver genes in cancer. To analyze mutation distribution in protein tertiary structures, we applied a novel three dimensional permutation test to the mutation positions. We analyzed somatic mutation datasets of 21...
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