Article

Maternal Obesity Effect on Offspring Pancreatic Endocrine Cells: Investigation of the Cell Transdifferentiation

2023-06-13

Abstract excerpt

Type 2 Diabetes (T2D) is a disease characterized by impaired functioning of pancreatic beta cells. In the later stages of the disease, beta cell dysfunction is defined as a decrease in functional cell count. Our hypothesis was that obesity-induced hyperglycemia of the mother could lead to dedifferentiation and/or transdifferentiation in their offspring's pancreatic beta cells. In our study, the mother Wistar rats...

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Literature Corpus work: 585bdb7a-9df2-5ed2-9417-1f5ddf79c7e7
DOI: 10.21203/rs.3.rs-3024860/v1

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