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Article

A new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification.

Human pathology - 1 Apr 2016

Guérin Maxime, Thariat Juliette, Ouali Mounia, Bouvier Corinne, Decouvelaere Anne-Valérie, Cassagnau Elisabeth, Aubert Sébastien, Lepreux Sébastien, Coindre Jean-Michel, Valmary-Degano Séverine, Larousserie Frédérique, Meilleroux Julie, Projetti Fabrice, Stock Nathalie, Galant Christine, Marie Béatrice, Peyrottes Isabelle, de Pinieux Gonzague, Gomez-Brouchet Anne

Abstract excerpt

In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spectrum of mandibular osteosarcoma using immunohistochemistry and molecular techniques (quantitative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Identifiers

PMID: 26997440
DOI: 10.1016/j.humpath.2015.11.012

Genes

MDM2
RASAL1
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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