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Article

Malignant transformation of fibrous dysplasia in long bones: a clinicopathological and molecular study of 19 cases.

Journal of clinical pathology - 17 Apr 2026

Dong Rongfang, Ding Yi, Su Yongbin, Deng Zhiping, Gao Ran, Li Lan, Zhang Tingting, Zhang Wen

Abstract excerpt

AIMS: Malignant transformation of fibrous dysplasia (FD) in long bones is very rare. This study aimed to explore its clinicopathological and molecular characteristics to reveal the diagnostic features and pathogenesis. METHODS: We conducted a clinicopathological analysis of 19 FD-associated sarcomas. Sanger and next-generation sequencing were used to detect molecular alterations, and clinical, radiological and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41708313
DOI: 10.1136/jcp-2025-210292

Genes

CDKN2A
GNAS
KDM6A
TERT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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