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Article

Osteosarcomas With Few Chromosomal Alterations or Adult Onset Are Genetically Heterogeneous.

Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2024

Difilippo Valeria, Saba Karim H, Styring Emelie, Magnusson Linda, Nilsson Jenny, Nathrath Michaela, Baumhoer Daniel, Nord Karolin H

Abstract excerpt

Osteosarcoma is the most common primary bone malignancy, often detected in children and adolescents and commonly associated with TP53 alterations along with a high number of chromosomal rearrangements. However, osteosarcoma can affect patients of any age, and some tumors display less genetic complexity. Besides TP53 variants, data on key driving mutations are lacking for many osteosarcomas, particularly those...

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PMID: 37931683
DOI: 10.1016/j.labinv.2023.100283

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