Article
Molecular pathology and its diagnostic use in bone tumors.
Cancer genetics - 1 May 2012
Szuhai Karoly, Cleton-Jansen Anne-Marie, Hogendoorn Pancras C W, Bovée Judith V M G
Abstract excerpt
Bone tumors are considered by most pathologists difficult to diagnose as they are rare, have overlapping morphology, need radiological correlation, and the usefulness of immunohistochemistry is limited, making conventional morphology the cornerstone of the diagnosis. Over the past decade, more and more has become known of the molecular background of bone tumors. Three groups of bone tumors are recognized, namely,...
Topics
- Bone Neoplasms
- Comparative Genomic Hybridization
- Cytogenetic Analysis
- Gene Amplification
- Genetic Testing
- Humans
- Karyotype
- Mutation
- Translocation, Genetic