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Article

GNAS mutations are not detected in parosteal and low-grade central osteosarcomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2015

Salinas-Souza Carolina, De Andrea Carlos, Bihl Michel, Kovac Michal, Pillay Nischalan, Forshew Tim, Gutteridge Alice, Ye Hongtao, Amary M Fernanda, Tirabosco Roberto, Toledo Silvia Regina Caminada, Baumhoer Daniel, Flanagan Adrienne M

Abstract excerpt

Parosteal osteosarcoma, low-grade central osteosarcoma, and fibrous dysplasia share similar histological features that may pose a diagnostic challenge. The detection of GNAS mutations in primary bone tumors has been useful in clinical practice for diagnosing fibrous dysplasia. However, the recent report of GNAS mutations being detected in a significant proportion of parosteal osteosarcoma challenges the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to GTP-Binding Protein alpha Subunits, Gs

Share to In Situ Hybridization, Fluorescence

Share to Multiplex Polymerase Chain Reaction

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Share to Proto-Oncogene Proteins c-mdm2

Source

Identifiers

PMID: 26248895
DOI: 10.1038/modpathol.2015.91

Genes

GNAS
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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