Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spontaneous in vitro senescence of glioma cells confirmed by an antibody against IDH1R132H.

Anticancer research - 1 Jun 2014

Stoczynska-Fidelus Ewelina, Och Waldemar, Rieske Piotr, Bienkowski Michal, Banaszczyk Mateusz, Winiecka-Klimek Marta, Zieba Jolanta, Janik Karolina, Rosiak Kamila, Treda Cezary, Stawski Robert, Radomiak-Zaluska Anna, Piaskowski Sylwester

Abstract excerpt

BACKGROUND: We have recently suggested that glioblastoma cells become spontaneously senescent in cell culture conditions. The antibody specific against IDH1(R132H) offers the perfect opportunity to verify this hypothesis. MATERIALS AND METHODS: We analyzed the features of senescence in 8 glioma c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Neoplastic Stem Cells

Share to Real-Time Polymerase Chain Reaction

Share to SOXB1 Transcription Factors

Source

Identifiers

PMID: 24922649

Genes

IDH1
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24922649-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spontaneous in vitro senescence of glioma cells confirmed by an antibody against IDH1R132H.PMID 24922649Read ↗

Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence.Semantic proximity Read ↗

The failure in the stabilization of glioblastoma-derived cell lines: spontaneous in vitro senescence as the main culprit.Semantic proximity Read ↗

IDH1 mutation diminishes aggressive phenotype in glioma stem cells.Semantic proximity Read ↗

Residual Disease in Glioma Recurrence: A Dangerous Liaison with SenescenceSemantic proximity Read ↗

Tumour cell-induced senescence-like state of macrophages plays a pivotal role in tumour stable growth after tumour cell emergence in immunocompetent conditionSemantic proximity Read ↗

Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition.Semantic proximity Read ↗

Generation of induced neural stem cells with inducible IDH1R132H for analysis of glioma development and drug testing.Semantic proximity Read ↗

Spontaneous Transformation of Human Adult Nontumorigenic Stem Cells to Cancer Stem Cells Is Driven by Genomic Instability in a Human Model of GlioblastomaSemantic proximity Read ↗

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 CellsSemantic proximity Read ↗

IDH1(R132H) mutation causes a less aggressive phenotype and radiosensitizes human malignant glioma cells independent of the oxygenation status.Semantic proximity Read ↗

Glioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions.Semantic proximity Read ↗

Evasion of Cell Senescence Leads to Medulloblastoma ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.