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Article

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.

Disease models & mechanisms - 1 Jan 2000

Santoriello Cristina, Deflorian Gianluca, Pezzimenti Federica, Kawakami Koichi, Lanfrancone Luisa, d'Adda di Fagagna Fabrizio, Mione Marina

Abstract excerpt

Constitutively active, 'oncogenic' H-RAS can drive proliferation and transformation in human cancer, or be a potent inducer of cellular senescence. Moreover, aberrant activation of the Ras pathway owing to germline mutations can cause severe developmental disorders. In this study we have generated transgenic zebrafish that constitutively express low levels, or can be induced to express high levels, of oncogenic...

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Identifiers

PMID: 19132118
DOI: 10.1242/dmm.001016
PMCID: PMC2615164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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