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Article

Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.

Neurobiology of disease - 1 Sept 2016

Getz Stephanie A, DeSpenza Tyrone, Li Meijie, Luikart Bryan W

Abstract excerpt

UNLABELLED: Phosphatase and tensin homolog (PTEN) is a major negative regulator of the Akt/mammalian target of rapamycin (MTOR) pathway. Mutations in PTEN have been found in a subset of individuals with autism and macrocephaly. Further, focal cortical dysplasia (FCD) has been observed in patients with PTEN mutations prompting us to examine the role of Pten in neuronal migration. The dentate gyrus of...

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Source

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Identifiers

PMID: 26992888
DOI: 10.1016/j.nbd.2016.03.010
PMCID: PMC5409093

Genes

PTEN
MTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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