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Article

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.

Disease models & mechanisms - 1 Jan 2000

Ljungberg M Cecilia, Sunnen C Nicole, Lugo Joaquin N, Anderson Anne E, D'Arcangelo Gabriella

Abstract excerpt

Malformations of the cerebral cortex known as cortical dysplasia account for the majority of cases of intractable childhood epilepsy. With the exception of the tuberous sclerosis complex, the molecular basis of most types of cortical dysplasia is completely unknown. Currently, there are no good animal models available that recapitulate key features of the disease, such as structural cortical abnormalities and...

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Source

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Identifiers

PMID: 19470613
DOI: 10.1242/dmm.002386
PMCID: PMC2707106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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