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Article

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

15 Jul 2002

Abstract excerpt

PTEN is a tumour suppressor gene involved in cell cycle control, apoptosis and mediation of adhesion and migration signalling. Germline mutations of PTEN in humans are associated with familial tumour syndromes, among them Cowden disease. Glioblastomas, highly malignant glial tumours of the central nervous system frequently show loss of PTEN. Recent reports have outlined some aspects of PTEN function in central...

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PMID: 12091320
DOI: 10.1242/dev.129.14.3513

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