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Article

Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes.

Molecular psychiatry - 1 Jul 2025

D'Amore Angelica, Sundberg Maria, Lin Rui, Lubbers Ella T, Winden Kellen D, Yu Lucy, Gawlinska Kinga, Gawlinski Dawid, Lopez Sam G, Choe Yongho, Wightman Emma V, Liang Yini, Modi Meera, Yuskaitis Christopher J, Lee Henry Hing Cheong, Rotenberg Alexander, Sahin Mustafa

Abstract excerpt

Phosphatase and Tensin Homolog (PTEN) is a dual-specific protein and lipid phosphatase that regulates AKT and downstream signaling of the mechanistic target of rapamycin (mTOR). PTEN functions as a tumor suppressor gene whose mutations result in PTEN Hamartoma Tumor Syndrome (PHTS) characterized by increased cancer risk and neurodevelopmental comorbidity. Here, we generated a novel neuron-specific Pten knock-out...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 39953287
DOI: 10.1038/s41380-025-02916-2

Genes

PTEN
PNN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes.PMID 39953287Read ↗

Development and Characterization of NEX-Pten, a Novel Forebrain Excitatory Neuron-Specific Knockout MouseSemantic proximity Read ↗

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The mTOR pathway genes <i>mTOR</i> , <i>Rheb</i> , <i>Depdc5</i> , <i>Pten</i> , and <i>Tsc1</i> have convergent and divergent impacts on cortical neuron development and functionSemantic proximity Read ↗

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