Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic anticipation in BRCA1/BRCA2 families after controlling for ascertainment bias and cohort effect.

Cancer - 15 Jun 2016

Guindalini Rodrigo Santa Cruz, Song Andrew, Fackenthal James D, Olopade Olufunmilayo I, Huo Dezheng

Abstract excerpt

BACKGROUND: Genetic anticipation, the earlier onset of disease in successive generations, has been reported in hereditary breast and ovarian cancer syndrome (HBOC), but little is known about its underlying mechanisms. Ascertainment bias has been suggested as a reason in previous studies. Likewise, cohort effect, which may be caused by environmental factors, can be misinterpreted as genetic anticipation. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Breast Neoplasms
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Germ-Line Mutation

Share to Ovarian Neoplasms

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 26992017
DOI: 10.1002/cncr.29972
PMCID: PMC4892951

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic anticipation in BRCA1/BRCA2 families after controlling for ascertainment bias and cohort effect.PMID 26992017Read ↗

Genetic anticipation of breast cancer among BRCA1/BRCA2 mutation carriers: A retrospective study.Semantic proximity Read ↗

Genetic anticipation of familial breast cancer with or without BRCA mutation in the Korean population.Semantic proximity Read ↗

Earlier Age of Breast Cancer Onset in Israeli BRCA Carriers-Is it a Real Phenomenon?Semantic proximity Read ↗

Earlier age of onset of BRCA mutation-related cancers in subsequent generations.Semantic proximity Read ↗

Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations.Semantic proximity Read ↗

Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome.Semantic proximity Read ↗

Anticipation in hereditary breast cancer.Semantic proximity Read ↗

Calculating Future 10-Year Breast Cancer Risks in Risk-Adapted Surveillance: A Method Comparison and Application in Clinical Practice.Semantic proximity Read ↗

Clinical Evidence of Disease Anticipation in Families Segregating a <i>C9orf72</i> Repeat ExpansionSemantic proximity Read ↗

Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families.Semantic proximity Read ↗

Bias Correction Methods Explain Much of the Variation Seen in Breast Cancer Risks of BRCA1/2 Mutation Carriers.Semantic proximity Read ↗

Assessing changes in ages at onset over successive generation: an application to breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.