Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Earlier age of onset of BRCA mutation-related cancers in subsequent generations.

Cancer - 15 Jan 2012

Litton Jennifer K, Ready Kaylene, Chen Huiqin, Gutierrez-Barrera Angelica, Etzel Carol J, Meric-Bernstam Funda, Gonzalez-Angulo Ana M, Le-Petross Huong, Lu Karen, Hortobagyi Gabriel N, Arun Banu K

Abstract excerpt

BACKGROUND: Women who are diagnosed with a deleterious mutation in either breast cancer (BRCA) gene have a high risk of developing breast and ovarian cancers at young ages. In this study, the authors assessed age at diagnosis in 2 generations of families with known mutations to investigate for earlier onset in subsequent generations. METHODS: Of the 132 BRCA-positive women with breast cancer who participated in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Genetic Predisposition to Disease

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 21913181
DOI: 10.1002/cncr.26284
PMCID: PMC4369377

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Earlier age of onset of BRCA mutation-related cancers in subsequent generations.PMID 21913181Read ↗

Genetic anticipation of breast cancer among BRCA1/BRCA2 mutation carriers: A retrospective study.Semantic proximity Read ↗

Genetic anticipation in BRCA1/BRCA2 families after controlling for ascertainment bias and cohort effect.Semantic proximity Read ↗

Earlier Age of Breast Cancer Onset in Israeli BRCA Carriers-Is it a Real Phenomenon?Semantic proximity Read ↗

Anticipation in hereditary breast cancer.Semantic proximity Read ↗

Hereditary susceptibility to breast cancer: significance of age of onset in family history and contribution of BRCA1 and BRCA2.Semantic proximity Read ↗

Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?Semantic proximity Read ↗

Does the age of breast cancer diagnosis in first-degree relatives impact on the risk of breast cancer in BRCA1 and BRCA2 mutation carriers?Semantic proximity Read ↗

Proven non-carriers in BRCA families have an earlier age of onset of breast cancer.Semantic proximity Read ↗

Assessing changes in ages at onset over successive generation: an application to breast cancer.Semantic proximity Read ↗

Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer.Semantic proximity Read ↗

BRCA mutations, molecular markers, and clinical variables in early-onset breast cancer: a population-based study.Semantic proximity Read ↗

BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.