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Article

Assessing changes in ages at onset over successive generation: an application to breast cancer.

Genetic epidemiology - 1 Jan 2000

Hsu L, Zhao L P, Malone K E, Daling J R

Abstract excerpt

Decreased age at onset in successive generations has been observed for a number of diseases. Two nonparametric matched and unmatched test statistics are proposed, taking into account not only current age or age at death for unaffected individuals and age at disease onset for affected individuals, but also possible correlations among family members. Both are asymptotically normal with readily estimated variances...

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Identifiers

PMID: 10603456
DOI: 10.1002/(SICI)1098-2272(200001)18:1<17::AID-GEPI2>3.0.CO;2-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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