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Article

Bias Correction Methods Explain Much of the Variation Seen in Breast Cancer Risks of BRCA1/2 Mutation Carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2015

Vos Janet R, Hsu Li, Brohet Richard M, Mourits Marian J E, de Vries Jakob, Malone Kathleen E, Oosterwijk Jan C, de Bock Geertruida H

Abstract excerpt

PURPOSE: Recommendations for treating patients who carry a BRCA1/2 gene are mainly based on cumulative lifetime risks (CLTRs) of breast cancer determined from retrospective cohorts. These risks vary widely (27% to 88%), and it is important to understand why. We analyzed the effects of methods of risk estimation and bias correction and of population factors on CLTRs in this retrospective clinical cohort of BRCA1/2...

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Source

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Identifiers

PMID: 26150446
DOI: 10.1200/JCO.2014.59.0463
PMCID: PMC4979233

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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