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Article

Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome.

Biometrics - 1 Dec 2011

Boonstra Philip S, Mukherjee Bhramar, Taylor Jeremy M G, Nilbert Mef, Moreno Victor, Gruber Stephen B

Abstract excerpt

Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation subtypes known to be associated with the disease phenotype. In this article, we posit a Bayesian approach to infer genetic anticipation under flexible random effects models for...

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Identifiers

PMID: 21627626
DOI: 10.1111/j.1541-0420.2011.01607.x
PMCID: PMC3176998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome.PMID 21627626Read ↗

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