Article
Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families.
Psychiatric genetics - 1 Sept 2001
Visscher P M, Yazdi M H, Jackson A D, Schalling M, Lindblad K, Yuan Q P, Porteous D, Muir W J, Blackwood D H
Abstract excerpt
Age-at-onset (AAO) in a number of extended families ascertained for bipolar disorder was analysed using survival analysis techniques, fitting proportional hazards models to estimate the fixed effects of sex, year of birth, and generation, and a random polygenic genetic effect. Data comprised the AAO (for 171 affecteds) or age when last seen (ALS) for 327 unaffecteds, on 498 individuals in 27 families. ALS was...
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