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Article

Dicer1 functions as a haploinsufficient tumor suppressor.

Genes & development - 1 Dec 2009

Kumar Madhu S, Pester Ryan E, Chen Cindy Y, Lane Keara, Chin Christine, Lu Jun, Kirsch David G, Golub Todd R, Jacks Tyler

Abstract excerpt

While the global down-regulation of microRNAs (miRNAs) is a common feature of human tumors, its genetic basis is largely undefined. To explore this question, we analyzed the consequences of conditional Dicer1 mutation (Dicer1 "floxed" or Dicer1(fl)) on several mouse models of cancer. Here we show Dicer1 functions as a haploinsufficient tumor suppressor gene. Deletion of a single copy of Dicer1 in tumors from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19903759
DOI: 10.1101/gad.1848209
PMCID: PMC2788328

Genes

DICER1

Provenance

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