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Article

microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts

24 Oct 2013

Abstract excerpt

Polycomb group protein BMI1 is an important regulator of senescence, aging, and cancer. On one hand, it is overexpressed in cancer cells and is required for self-renewal of stem cells. On the other hand, it is downregulated during senescence and aging. MicroRNAs have emerged as major regulators of almost every gene associated with cancer, aging, and related pathologies. At present, very little is known about the...

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PMID: 24091627
DOI: 10.4161/cc.26592

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