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Article

Acinar phenotype is preserved in human exocrine pancreas cells cultured at low temperature: implications for lineage-tracing of β-cell neogenesis.

Bioscience reports - 1 Jun 2016

Mfopou Josué K, Houbracken Isabelle, Wauters Elke, Mathijs Iris, Song Imane, Himpe Eddy, Baldan Jonathan, Heimberg Harry, Bouwens Luc

Abstract excerpt

The regenerative medicine field is expanding with great successes in laboratory and preclinical settings. Pancreatic acinar cells in diabetic mice were recently converted into β-cells by treatment with ciliary neurotrophic factor (CNTF) and epidermal growth factor (EGF). This suggests that human acinar cells might become a cornerstone for diabetes cell therapy in the future, if they can also be converted into...

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Identifiers

PMID: 26987985
DOI: 10.1042/BSR20150259
PMCID: PMC4859086

Genes

CNTF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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