Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acinar plasticity: development of a novel in vitro model to study human acinar-to-duct-to-islet differentiation.

Pancreas - 1 May 2007

Lipsett Mark A, Castellarin Mauro L, Rosenberg Lawrence

Abstract excerpt

OBJECTIVES: The plasticity of pancreatic tissue is demonstrated in many pancreatic diseases. It has previously been shown that pancreatic islet-to-duct transformation and acinoductal metaplasia have been associated with both pancreatic regeneration and adenocarcinoma in various in vivo and in vitro settings. Understanding this inherent morphogenetic plasticity of the adult pancreas could lead to new therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amylases
Share to C-Peptide
Share to Gastrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Growth Factor

Share to Keratin-19

Share to Metaplasia

Share to Pancreatic Ducts

Share to Pancreatitis-Associated Proteins

Source

Identifiers

PMID: 17446845
DOI: 10.1097/MPA.0b013e3180335c80

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acinar plasticity: development of a novel in vitro model to study human acinar-to-duct-to-islet differentiation.PMID 17446845Read ↗

Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture.Semantic proximity Read ↗

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and DiseaseSemantic proximity Read ↗

Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.Semantic proximity Read ↗

Islet morphogenesis and stem cell markers.Semantic proximity Read ↗

Differentiation of pancreatic acinar cells into duct-like cells in vitro.Semantic proximity Read ↗

The Human Endocrine Pancreas: New Insights on Replacement and RegenerationSemantic proximity Read ↗

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor CellsSemantic proximity Read ↗

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes.Semantic proximity Read ↗

Pancreatic organogenesis--developmental mechanisms and implications for therapy.Semantic proximity Read ↗

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation PotentialSemantic proximity Read ↗

Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro.Semantic proximity Read ↗

Normal human pancreas cultures display functional ductal characteristics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.