A novel explant outgrowth culture model for mouse pancreatic acinar cells with long-term maintenance of secretory phenotype.

doi:10.1016/j.ejcb.2011.07.004

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Article

A novel explant outgrowth culture model for mouse pancreatic acinar cells with long-term maintenance of secretory phenotype.

European journal of cell biology - 1 Dec 2011

Bläuer Merja, Nordback Isto, Sand Juhani, Laukkarinen Johanna

Abstract excerpt

The development of in vitro models able to support the long-term viability and function of acinar cells is critical for exploring pancreatic pathophysiology. Despite considerable efforts, no long-term culture models for non-transformed pancreatic acini exist. Our aim was to develop and validate culture conditions for this purpose. An explant outgrowth culture design was established in which mouse pancreatic...

Topics

Acinar Cells
Animals
Cell Survival
Cytological Techniques
Immunohistochemistry
Male
Mice
Mice, Inbred C57BL
Pancreas, Exocrine
Phenotype

Source

Open in PubMed

Identifiers

PMID: 21906833
DOI: 10.1016/j.ejcb.2011.07.004

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