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Article

Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.

Gastroenterology - 1 Aug 2011

Houbracken Isabelle, de Waele Evelien, Lardon Jessy, Ling Zhidong, Heimberg Harry, Rooman Ilse, Bouwens Luc

Abstract excerpt

BACKGROUND & AIMS: Animal studies have indicated that pancreatic exocrine acinar cells have phenotypic plasticity. In rodents, acinar cells can differentiate into ductal precursors that can be converted to pancreatic ductal adenocarcinoma or insulin-producing endocrine cells. However, little is known about human acinar cell plasticity. We developed nongenetic and genetic lineage tracing methods to study the fate...

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Source

Identifiers

PMID: 21703267
DOI: 10.1053/j.gastro.2011.04.050

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SOX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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