Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.

Medicine - 22 Sept 2023

Kaneko Masanao, Nakashima Mitsuko, Sugiura Kiichi, Ishida Natsuki, Tamura Satoshi, Tani Shinya, Yamade Mihoko, Hamaya Yasushi, Osawa Satoshi, Tatsuta Kyota, Kurachi Kiyotaka, Baba Satoshi, Iwashita Yuji, Arai Tomio, Sugimura Haruhiko, Maekawa Masato, Sugimoto Ken, Iwaizumi Moriya

Abstract excerpt

Although immunohistochemistry (IHC) for mismatch repair (MMR) proteins (MMR IHC) is used to identify DNA MMR status, universal screening of all patients with colorectal cancer (CRC) using a combination of both MMR IHC and genetic testing for the BRAFV600E mutation is limited in Japan. This study aimed to better understand the histopathological characteristics of CRCs, which exhibit both deficient mismatch repair...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Carcinoma, Medullary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Genetic Testing

Share to Mutation

Share to MutL Protein Homolog 1

Source

Open in PubMed Open full text

Identifiers

PMID: 37746995
DOI: 10.1097/MD.0000000000035022
PMCID: PMC10519469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.PMID 37746995Read ↗

Clinicopathological and molecular characterization of deficient mismatch repair colorectal cancer.Semantic proximity Read ↗

Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.Semantic proximity Read ↗

Exploring the expression and the prognosis of mismatch repair protein and PD-L1 in colorectal cancerSemantic proximity Read ↗

DNA Mismatch Repair-Deficient Colorectal Carcinoma: Referral Rate for Genetic Cancer Risk Assessment in a Brazilian Cancer Center.Semantic proximity Read ↗

Patterns and characteristics of mismatch repair deficiency colorectal cancer from central ChinaSemantic proximity Read ↗

Mismatch Repair Deficiency in Colorectal Adenocarcinoma: Clinical, Pathological and Prognostic Features, a Single Center’s Experience of 1002 CasesSemantic proximity Read ↗

Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome.Semantic proximity Read ↗

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.Semantic proximity Read ↗

Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas.Semantic proximity Read ↗

Clinical significance of MLH1/MSH2 for stage II/III sporadic colorectal cancerSemantic proximity Read ↗

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.Semantic proximity Read ↗

Mismatch Repair Gene Deficiency in Ovarian Cancer: A Clinicopathological Analysis of MLH1, PMS2, MSH2, and MSH6 Mutations Across Histological Subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.