Article
Development of a high-resolution melting method for the screening of TNFAIP3 gene mutations.
Oncology reports - 1 May 2016
Chang Yuli Christine, Chang Ya-Sian, Chang Chun-Chi, Liu Ta-Chih, Ko Ying-Chin, Lee Chien-Chin, Chang Shun-Jen, Chang Jan-Gowth
Abstract excerpt
Tumor necrosis factor, α-induced protein 3 (TNFAIP3) which encodes a ubiquitin-modifying enzyme (A20), acts as a negative regulator of the NF-κB pathway, and in lymphoma and autoimmune diseases it is frequently inactivated by mutations and/or deletions. We investigated the prevalence of the inactivation of TNFAIP3 in oral squamous cell carcinoma (OSCC). DNA was extracted from 81 cases of OSCC and 50 peripheral...
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