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Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae : Actions of Ciprofloxacin against Gyrase and Topoisomerase IV

4 Mar 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Fluoroquinolones make up a critically important class of antibacterials administered worldwide to treat human infections. However, their clinical utility has been curtailed by target-mediated resistance, which is caused by mutations in the fluoroquinolone targets, gyrase and topoisomerase IV. An important pathogen that has been affected by this resistance is...

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PMID: 38606464
DOI: 10.1021/acsinfecdis.4c00041

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