Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ciprofloxacin dimers target gyrase in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Jun 2004

Gould Katherine A, Pan Xiao-Su, Kerns Robert J, Fisher L Mark

Abstract excerpt

We have examined the antipneumococcal activities of novel quinolone dimers in which ciprofloxacin was tethered to itself or to pipemidic acid by linkage of C-7 piperazinyl rings. Symmetric 2,6-lutidinyl- and trans-butenyl-linked ciprofloxacin dimers (dimers 1 and 2, respectively) and a pipemidic acid-ciprofloxacin dimer (dimer 3) had activities against Streptococcus pneumoniae strain 7785 that were comparable to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Catalysis
Share to Ciprofloxacin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Gyrase

Share to DNA Topoisomerase IV

Share to Microbial Sensitivity Tests

Share to Nucleic Acid Conformation

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 15155208
DOI: 10.1128/AAC.48.6.2108-2115.2004
PMCID: PMC415600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ciprofloxacin dimers target gyrase in Streptococcus pneumoniae.PMID 15155208Read ↗

Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli.Semantic proximity Read ↗

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus.Semantic proximity Read ↗

Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.Semantic proximity Read ↗

Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.Semantic proximity Read ↗

Unique biological properties and molecular mechanism of 5,6-bridged quinolones.Semantic proximity Read ↗

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.Semantic proximity Read ↗

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.Semantic proximity Read ↗

Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV.Semantic proximity Read ↗

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.Semantic proximity Read ↗

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniaeSemantic proximity Read ↗

Comparative in vitro activity of PGE 9262932 and fluoroquinolones against Canadian clinical Streptococcus pneumoniae isolates, including molecularly characterized ciprofloxacin-resistant isolates.Semantic proximity Read ↗

Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.