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Article

Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.

ACS chemical biology - 20 Dec 2013

Aldred Katie J, Schwanz Heidi A, Li Gangqin, McPherson Sylvia A, Turnbough Charles L, Kerns Robert J, Osheroff Neil

Abstract excerpt

Quinolones, which target gyrase and topoisomerase IV, are the most widely prescribed antibacterials worldwide. Unfortunately, their use is threatened by the increasing prevalence of target-mediated drug resistance. Greater than 90% of mutations that confer quinolone resistance act by disrupting enzyme-drug interactions coordinated by a critical water-metal ion bridge. Quinazolinediones are quinolone-like drugs...

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Identifiers

PMID: 24047414
DOI: 10.1021/cb400592n
PMCID: PMC3870039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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