Drug Interactions with <i>Bacillus anthracis</i> Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance

Abstract excerpt

Bacillus anthracis, the causative agent of anthrax, is considered a serious threat as a bioweapon. The drugs most commonly used to treat anthrax are quinolones, which act by increasing the levels of DNA cleavage mediated by topoisomerase IV and gyrase. Quinolone resistance most often is associated with specific serine mutations in these enzymes. Therefore, to determine the basis for quinolone action and...

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