Article
Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Jul 1995
Kitamura A, Hoshino K, Kimura Y, Hayakawa I, Sato K
Abstract excerpt
Inhibitory effects of five quinolones against DNA gyrases purified from four quinolone-resistant clinical isolates of Pseudomonas aeruginosa and the quinolone-susceptible strain PAO1 were examined. All of the quinolone-resistant strains tested were found to be DNA gyrase mutants. The 50% inhibito...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Macromolecular Substances
- Microbial Sensitivity Tests
- Mutation
- Pseudomonas aeruginosa
- Quinolones
- Spiro Compounds
- Structure-Activity Relationship
- Topoisomerase II Inhibitors