Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice

27 Sept 2021

Abstract excerpt

BACKGROUND: Our recent studies demonstrate that the focal adhesion protein Kindlin-2 exerts crucial functions in the mesenchymal stem cells, mature osteoblasts and osteocytes in control of early skeletal development and bone homeostasis in mice. However, whether Kindlin-2 plays a role in osteoprogenitors remains unclear. MATERIALS AND METHODS: ) and control littermates were isolated and determined for their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Connective tissue disorders research
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34934625
DOI: 10.1016/j.jot.2021.08.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in micePMID 34934625Read ↗

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritisSemantic proximity Read ↗

Kindlin-3 Mutation in Mesenchymal Stem Cells Results in Enhanced ChondrogenesisSemantic proximity Read ↗

Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.Semantic proximity Read ↗

The transcriptome of regenerating zebrafish scales identifies genes involved in human bone diseaseSemantic proximity Read ↗

Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophySemantic proximity Read ↗

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal DiseaseSemantic proximity Read ↗

Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts.Semantic proximity Read ↗

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineagesSemantic proximity Read ↗

Progressive skeletal defects caused by Kindlin3 deficiency, a model of autosomal recessive osteopetrosis in humans.Semantic proximity Read ↗

Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4 versus Aggrecan transgene in miceSemantic proximity Read ↗

Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation.Semantic proximity Read ↗

Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral OssificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.