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Article

Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Development (Cambridge, England) - 15 Feb 2016

Tonna Stephen, Poulton Ingrid J, Taykar Farzin, Ho Patricia W M, Tonkin Brett, Crimeen-Irwin Blessing, Tatarczuch Liliana, McGregor Narelle E, Mackie Eleanor J, Martin T John, Sims Natalie A

Abstract excerpt

The majority of the skeleton arises by endochondral ossification, whereby cartilaginous templates expand and are resorbed by osteoclasts then replaced by osteoblastic bone formation. Ephrin B2 is a receptor tyrosine kinase expressed by osteoblasts and growth plate chondrocytes that promotes osteoblast differentiation and inhibits osteoclast formation. We investigated the role of ephrin B2 in endochondral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26755702
DOI: 10.1242/dev.125625

Genes

ADAMTS4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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