Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-A2 Alleles Mediate Alzheimer's Disease by Altering Hippocampal Volume.

Molecular neurobiology - 1 May 2017

Wang Zi-Xuan, Wang Hui-Fu, Tan Lin, Sun Fu-Rong, Tan Meng-Shan, Tan Chen-Chen, Jiang Teng, Tan Lan, Yu Jin-Tai

Abstract excerpt

HLA-A is a locus of the major histocompatibility complex situated on chromosome 6p21.3. HLA-A has been shown to be associated with susceptibility to Alzheimer's disease (AD). In this study, we firstly investigated the association of gene variants in HLA-A and brain structures on MRI in a large sample from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to explore the effects of HLA-A on AD pathogenesis. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Alzheimer Disease
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Hippocampus

Share to HLA-A2 Antigen

Share to Magnetic Resonance Imaging

Share to Organ Size

Source

Identifiers

PMID: 26979752
DOI: 10.1007/s12035-016-9832-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-A2 Alleles Mediate Alzheimer's Disease by Altering Hippocampal Volume.PMID 26979752Read ↗

Genetic Association of HLA Gene Variants with MRI Brain Structure in Alzheimer's Disease.Semantic proximity Read ↗

Effects of HLA-DRB1/DQB1 Genetic Variants on Neuroimaging in Healthy, Mild Cognitive Impairment, and Alzheimer's Disease Cohorts.Semantic proximity Read ↗

Association between HLA-A alleles and Alzheimer's disease in a southern Chinese community.Semantic proximity Read ↗

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.Semantic proximity Read ↗

Microglia – mediated immunity partly contributes to the genetic association between Alzheimer’s disease and hippocampal volumeSemantic proximity Read ↗

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control studySemantic proximity Read ↗

Genetic, psychosocial and clinical factors associated with hippocampal volume in the general population.Semantic proximity Read ↗

Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support.Semantic proximity Read ↗

HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study.Semantic proximity Read ↗

ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.Semantic proximity Read ↗

A TREML2 missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects.Semantic proximity Read ↗

A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.