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Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

28 Mar 2017

Abstract excerpt

BACKGROUND: Alzheimer disease (AD) is a progressive disorder that affects cognitive function. There is increasing support for the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD. The immunoregulatory human leukocyte antigen (HLA) complex has been linked to susceptibility for a number of neurodegenerative diseases, including AD; however, studies to date have failed to...

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PMID: 28350795
DOI: 10.1371/journal.pmed.1002272

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