Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-C07:01 and HLA-DQB102:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study.

Brain, behavior, and immunity - 1 Jan 2024

Gao Yaqing, Su Binbin, Luo Yanan, Tian Yaohua, Hong Shenda, Gao Song, Xie Junqing, Zheng Xiaoying

Abstract excerpt

BACKGROUND: Neuroinflammation and aberrant immune regulation are increasingly implicated in the pathophysiology of white matter hyperintensities (WMH), an imaging marker of cerebrovascular pathologies and predictor of cognitive impairment. The role of human leukocyte antigen (HLA) genes, critical in immunoregulation and associated with susceptibility to neurodegenerative diseases, in WMH pathophysiology remains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dementia

Share to Gene Frequency

Share to Haplotypes

Share to HLA-C Antigens

Share to HLA-DRB1 Chains

Share to White Matter

Source

Identifiers

PMID: 37884160
DOI: 10.1016/j.bbi.2023.10.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study.PMID 37884160Read ↗

HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signalingSemantic proximity Read ↗

Meta-analyses of genome-wide association studies identify novel loci influencing Japanese white matter hyperintensities.Semantic proximity Read ↗

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRISemantic proximity Read ↗

Protective Effect of Human Leukocyte Antigen (HLA) Allele DRB1*13:02 on Age-Related Brain Gray Matter Volume Reduction in Healthy Women.Semantic proximity Read ↗

The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE $${{\varepsilon }}$$4–negative Japanese adultsSemantic proximity Read ↗

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control studySemantic proximity Read ↗

Genetic Association of HLA Gene Variants with MRI Brain Structure in Alzheimer's Disease.Semantic proximity Read ↗

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling.Semantic proximity Read ↗

HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study.Semantic proximity Read ↗

Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.Semantic proximity Read ↗

The immunogenetics of neurological disease.Semantic proximity Read ↗

Immunogenetic Factors of Neurodegenerative Diseases: The Role of HLA Class IISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.