Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.

Neurobiology of aging - 1 Jan 2000

Sleegers Kristel, den Heijer Tom, van Dijk Ewoud J, Hofman Albert, Bertoli-Avella Aida M, Koudstaal Peter J, Breteler Monique M B, van Duijn Cornelia M

Abstract excerpt

Despite biological support for a role of angiotensin converting enzyme (ACE) in Alzheimer's disease (AD), studies assessing the ACE I/D polymorphism in AD are conflicting. We re-evaluated this association in the Rotterdam Study, a population-based cohort study. The mechanism of association was further explored by adjusting for vascular factors, and by analysing atrophy, white matter lesions and infarcts on MRI in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrophy
Share to Amygdala

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cerebrovascular Disorders

Share to Hippocampus

Share to Nerve Fibers, Myelinated

Share to Netherlands

Share to Peptidyl-Dipeptidase A

Share to Sex Factors

Source

Identifiers

PMID: 15917098
DOI: 10.1016/j.neurobiolaging.2004.09.011

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.PMID 15917098Read ↗

Alzheimer disease risk and genetic variation in ACE: a meta-analysis.Semantic proximity Read ↗

ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementiaSemantic proximity Read ↗

Angiotensin-converting enzyme polymorphisms AND Alzheimer's disease susceptibility: An updated meta-analysis.Semantic proximity Read ↗

The ACE gene and Alzheimer's disease susceptibility.Semantic proximity Read ↗

Angiotensin-converting enzyme insertion/deletion polymorphism is associated with cerebral white matter changes in Alzheimer's disease.Semantic proximity Read ↗

Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity.Semantic proximity Read ↗

Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study.Semantic proximity Read ↗

Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's DiseaseSemantic proximity Read ↗

Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population.Semantic proximity Read ↗

Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI.Semantic proximity Read ↗

Association between angiotensin-converting enzyme and Alzheimer disease.Semantic proximity Read ↗

Artificial intelligence-assisted meta-analysis of the frequency of<i>ACE</i>I/D polymorphisms in centenarians and other long-lived individualsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.